Heather Huddleston, MD

Associate Prof of Clin OBGYN
Ob/Gyn, Reproductive Sciences
+1 415 353-3040

Dr. Heather Huddleston is a specialist in reproductive endocrinology (hormonal function) and infertility. She cares for patients with a wide array of reproductive and fertility concerns. She has special interests in polycystic ovary syndrome (PCOS), recurrent pregnancy loss and uterine disorders, including Asherman's syndrome (a condition involving scar tissue in the uterus). She also has expertise in techniques for diagnosing and treating complex uterine causes of infertility, including hysteroscopy, in which a thin, lighted tube is inserted into the vagina to allow examination of the cervix and interior of the uterus.

As director of the UCSF PCOS Clinic and research program, Huddleston oversees multiple research projects focused on improving medical understanding of PCOS. She also conducts research on recurrent pregnancy loss and treatment approaches for uterine factor infertility (abnormalities of the uterus that interfere with pregnancy). She has spoken on her findings all over the country, and her research has been widely published in scientific journals.

Huddleston earned her medical degree at Harvard Medical School. She completed a residency in obstetrics and gynecology, followed by a fellowship in reproductive endocrinology and infertility, at Brigham and Women's Hospital and Massachusetts General Hospital.

Huddleston is a member of the American Society for Reproductive Medicine and American College of Obstetricians and Gynecologists.

Publications: 

In Utero Exposure to Maternal COVID-19 Vaccination and Offspring Neurodevelopment at 12 and 18 Months.

JAMA pediatrics

Jaswa EG, Cedars MI, Lindquist KJ, Bishop SL, Kim YS, Kaing A, Prahl M, Gaw SL, Corley J, Hoskin E, Cho YJ, Rogers E, Huddleston HG

Improved Clinical Outcomes with Dynamic, Force-Controlled, Gap-Balancing in Posterior-Stabilized Total Knee Arthroplasty.

The Journal of arthroplasty

Valtanen RS, Seligson M, Huddleston HG, Angibaud L, Huddleston JI

Associations of Polycystic Ovary Syndrome With Indicators of Brain Health at Midlife in the CARDIA Cohort.

Neurology

Huddleston HG, Jaswa EG, Casaletto KB, Neuhaus J, Kim C, Wellons M, Launer LJ, Yaffe K

Metabolic and endocrine status associate with obstructive sleep apnea risk among patients with polycystic ovary syndrome.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Christ JP, Shinkai K, Corley J, Pasch L, Cedars MI, Huddleston HG

Association between social media use for medical information during pregnancy and likelihood of vaccination against COVID-19.

AJOG global reports

Jaswa EG, Lindquist KJ, Hariton E, Aliaga KE, Cedars MI, Huddleston HG

Decision regret among women considering planned oocyte cryopreservation: a prospective cohort study.

Journal of assisted reproduction and genetics

Jaswa EG, Pasch LA, McGough A, Wong R, Corley J, Cedars MI, Huddleston HG

Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.

Journal of the American Heart Association

Kim C, Catov J, Schreiner PJ, Appiah D, Wellons MF, Siscovick D, Calderon-Margalit R, Huddleston H, Ebong IA, Lewis CE

Endophenotypic correlates of cognitive function in reproductive-age individuals with polycystic ovary syndrome.

F&S reports

Huddleston HG, Casaletto KB, Jaswa EG, Rasgon NL, Maki PP, Cedars MI, Pasch L

Polycystic ovary syndrome is associated with nonalcoholic steatohepatitis in women of reproductive age.

Hepatology communications

Maldonado SS, Grab J, Wang CW, Huddleston H, Cedars M, Sarkar M

Early pregnancy anxiety during the COVID-19 pandemic: preliminary findings from the UCSF ASPIRE study.

BMC pregnancy and childbirth

Morris JR, Jaswa E, Kaing A, Hariton E, Andrusier M, Aliaga K, Davis M, Cedars MI, Huddleston HG

Decision regret after failed autologous in vitro fertilization in women ≥42 years of age.

Fertility and sterility

Huang D, Jaswa E, Ransohoff A, Boscardin WJ, Pasch L, Cedars M, Huddleston H

COVID-19 vaccination patterns and attitudes among American pregnant individuals.

American journal of obstetrics & gynecology MFM

Huddleston HG, Jaswa EG, Lindquist KJ, Kaing A, Morris JR, Hariton E, Corley J, Hoskin E, Gaw SL, Cedars MI

Autologous platelet-rich plasma treatment for moderate-severe Asherman syndrome: the first experience.

Journal of assisted reproduction and genetics

Aghajanova L, Sundaram V, Kao CN, Letourneau JM, Manvelyan E, Cedars MI, Huddleston HG

Association of obstructive sleep apnea risk with depression and anxiety symptoms in women with polycystic ovary syndrome.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Zhou X, Jaswa E, Pasch L, Shinkai K, Cedars MI, Huddleston HG

Increased Body Mass Index Is Associated With A Nondilutional Reduction in Antimüllerian Hormone.

The Journal of clinical endocrinology and metabolism

Jaswa EG, Rios JS, Cedars MI, Santoro NF, Pavone MEG, Legro RS, Huddleston HG

Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.

The Journal of clinical endocrinology and metabolism

Rios JS, Greenwood EA, Pavone MEG, Cedars MI, Legro RS, Diamond MP, Santoro N, Sun F, Robinson RD, Christman G, Zhang H, Huddleston HG

Polycystic ovary syndrome (PCOS) is associated with NASH severity and advanced fibrosis.

Liver international : official journal of the International Association for the Study of the Liver

Sarkar M, Terrault N, Chan W, Cedars MI, Huddleston HG, Duwaerts CC, Balitzer D, Gill RM

Insulin resistance in polycystic ovary syndrome: concept versus cutoff.

Fertility and sterility

Greenwood EA, Huddleston HG

Depression Over the Lifespan in a Population-Based Cohort of Women With Polycystic Ovary Syndrome: Longitudinal Analysis.

The Journal of clinical endocrinology and metabolism

Greenwood EA, Yaffe K, Wellons MF, Cedars MI, Huddleston HG

Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee.

The Journal of clinical endocrinology and metabolism

Carmina E, Azziz R, Bergfeld W, Escobar-Morreale HF, Futterweit W, Huddleston H, Lobo R, Olsen E

Interpregnancy interval and singleton pregnancy outcomes after frozen embryo transfer.

Fertility and sterility

Quinn MM, Rosen MP, Allen IE, Huddleston HG, Cedars MI, Fujimoto VY

Improved diagnostic performance for the diagnosis of polycystic ovary syndrome using age-stratified criteria.

Fertility and sterility

Ahmad AK, Quinn M, Kao CN, Greenwood E, Cedars MI, Huddleston HG

Decreased clinical pregnancy and live birth rates after short interval from delivery to subsequent assisted reproductive treatment cycle.

Human reproduction (Oxford, England)

Quinn MM, Rosen MP, Allen IE, Huddleston HG, Cedars MI, Fujimoto VY

Interpregnancy Interval and Singleton Live Birth Outcomes From In Vitro Fertilization.

Obstetrics and gynecology

Quinn MM, Rosen MP, Huddleston HG, Cedars MI, Fujimoto VY

Association among depression, symptom experience, and quality of life in polycystic ovary syndrome.

American journal of obstetrics and gynecology

Greenwood EA, Pasch LA, Cedars MI, Legro RS, Huddleston HG, Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicin

Insulin resistance is associated with depression risk in polycystic ovary syndrome.

Fertility and sterility

Greenwood EA, Pasch LA, Cedars MI, Legro RS, Eisenberg E, Huddleston HG, Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicin

To freeze or not to freeze: decision regret and satisfaction following elective oocyte cryopreservation.

Fertility and sterility

Greenwood EA, Pasch LA, Hastie J, Cedars MI, Huddleston HG

Continuum of polycystic ovary syndrome physiology.

Fertility and sterility

Huddleston HG

The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome.

Current opinion in gynecology and obstetrics

Sarkar M, Terrault N, Duwaerts CC, Tien P, Cedars MI, Huddleston H

Platelet-rich plasma in the management of Asherman syndrome: case report.

Journal of assisted reproduction and genetics

Aghajanova L, Cedars MI, Huddleston HG

In vitro evidence that platelet-rich plasma stimulates cellular processes involved in endometrial regeneration.

Journal of assisted reproduction and genetics

Aghajanova L, Houshdaran S, Balayan S, Manvelyan E, Irwin JC, Huddleston HG, Giudice LC

Antimüllerian hormone levels and antral follicle counts are not reduced compared with community controls in patients with rigorously defined unexplained infertility.

Fertility and sterility

Greenwood EA, Cedars MI, Santoro N, Eisenberg E, Kao CN, Haisenleder DJ, Diamond MP, Huddleston HG, National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human De

Age-stratified thresholds of anti-Müllerian hormone improve prediction of polycystic ovary syndrome over a population-based threshold.

Clinical endocrinology

Quinn MM, Kao CN, Ahmad AK, Haisenleder DJ, Santoro N, Eisenberg E, Legro RS, Cedars MI, Huddleston HG, NIH/NICHD Reproductive Medicine Network

Rotterdam criteria-based diagnostic subtype is not a strong predictor of cutaneous phenotype in patients with polycystic ovary syndrome: A cross-sectional study.

Journal of the American Academy of Dermatology

Schmidt TH, Okhovat JP, Khanijow K, Huddleston H, Cedars M, Pasch L, Wang ET, Lee J, Shinkai K

Transvaginal Obliteration of a Complex Uterine Arteriovenous Fistula Using Ethylene Vinyl Alcohol Copolymer.

Journal of vascular and interventional radiology : JVIR

Lehrman ED, Heller M, Poder L, Kerlan R, Huddleston HG, Kohi MP

Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.

Fertility research and practice

Reid SP, Kao CN, Pasch L, Shinkai K, Cedars MI, Huddleston HG

A higher prevalence of endometriosis among Asian women does not contribute to poorer IVF outcomes.

Journal of assisted reproduction and genetics

Yamamoto A, Johnstone EB, Bloom MS, Huddleston HG, Fujimoto VY

Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome.

International journal of women's dermatology

Afifi L, Saeed L, Pasch LA, Huddleston HG, Cedars MI, Zane LT, Shinkai K

Raising threshold for diagnosis of polycystic ovary syndrome excludes population of patients with metabolic risk.

Fertility and sterility

Quinn MM, Kao CN, Ahmad A, Lenhart N, Shinkai K, Cedars MI, Huddleston HG

Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome.

JAMA dermatology

Schmidt TH, Khanijow K, Cedars MI, Huddleston H, Pasch L, Wang ET, Lee J, Zane LT, Shinkai K

Vigorous exercise is associated with superior metabolic profiles in polycystic ovary syndrome independent of total exercise expenditure.

Fertility and sterility

Greenwood EA, Noel MW, Kao CN, Shinkai K, Pasch LA, Cedars MI, Huddleston HG

Putative role for insulin resistance in depression risk in polycystic ovary syndrome.

Fertility and sterility

Greenwood EA, Pasch LA, Shinkai K, Cedars MI, Huddleston HG

Polycystic Ovary Syndrome: Special Diagnostic and Therapeutic Considerations for Children.

Pediatric dermatology

Kamangar F, Okhovat JP, Schmidt T, Beshay A, Pasch L, Cedars MI, Huddleston H, Shinkai K

Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro.

Human reproduction (Oxford, England)

Piltonen TT, Chen JC, Khatun M, Kangasniemi M, Liakka A, Spitzer T, Tran N, Huddleston H, Irwin JC, Giudice LC

Oocyte donors' comprehension as assessed by the EDICT (Egg Donor Informed Consent Tool).

Fertility and sterility

Skillern AA, Cedars MI, Huddleston HG

Biomarkers of ovarian reserve in women with polycystic ovary syndrome.

Seminars in reproductive medicine

Huddleston HG

Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential.

The Journal of clinical endocrinology and metabolism

Piltonen TT, Chen J, Erikson DW, Spitzer TL, Barragan F, Rabban JT, Huddleston H, Irwin JC, Giudice LC

Phenotypic comparison of Caucasian and Asian women with polycystic ovary syndrome: a cross-sectional study.

Fertility and sterility

Wang ET, Kao CN, Shinkai K, Pasch L, Cedars MI, Huddleston HG

MI TKA: a risk factor for early revision surgery.

The journal of knee surgery

Mayle RE, Graw BP, Huddleston HG, Woolson ST, Goodman SB, Huddleston JI

Age-related differences in the reproductive and metabolic implications of polycystic ovarian syndrome: findings in an obese, United States population.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Johnstone EB, Davis G, Zane LT, Cedars MI, Huddleston HG

Advanced age and comorbidity increase the risk for adverse events after revision total hip arthroplasty.

The Journal of arthroplasty

Koenig K, Huddleston JI, Huddleston H, Maloney WJ, Goodman SB

Ethnic variation in estradiol metabolism in reproductive age Asian and white women treated with transdermal estradiol.

Fertility and sterility

Huddleston HG, Rosen MP, Gibson M, Cedars MI, Fujimoto VY

Asian ethnicity and fecundability in women with spontaneous conceptions.

Fertility and sterility

Wang ET, Fujimoto VY, Yeaton-Massey AJ, Vittinghoff E, Caughey AB, Huddleston HG

Asian immigrants to the United States are less likely to donate cryopreserved embryos for research use.

Fertility and sterility

Sharma H, Johnstone EB, Gates E, Sohn SH, Huddleston HG, Fujimoto VY

Physical activity in women with polycystic ovary syndrome: prevalence, predictors, and positive health associations.

American journal of obstetrics and gynecology

Lamb JD, Johnstone EB, Rousseau JA, Jones CL, Pasch LA, Cedars MI, Huddleston HG

Minimal incision surgery as a risk factor for early failure of total hip arthroplasty.

Clinical orthopaedics and related research

Graw BP, Woolson ST, Huddleston HG, Goodman SB, Huddleston JI

Racial and ethnic disparities in reproductive endocrinology and infertility.

American journal of obstetrics and gynecology

Huddleston HG, Cedars MI, Sohn SH, Giudice LC, Fujimoto VY

Health disparities: definitions and measurements.

American journal of obstetrics and gynecology

Dehlendorf C, Bryant AS, Huddleston HG, Jacoby VL, Fujimoto VY

Follicular fluid high density lipoprotein-associated micronutrient levels are associated with embryo fragmentation during IVF.

Journal of assisted reproduction and genetics

Browne RW, Bloom MS, Shelly WB, Ocque AJ, Huddleston HG, Fujimoto VY

Asian ethnicity is associated with decreased pregnancy rates following intrauterine insemination.

Reproductive biomedicine online

Lamb JD, Huddleston HG, Purcell KJ, Modan A, Farsani TT, Dingeldein MA, Vittinghoff E, Fujimoto VY

Fertilization rate is an independent predictor of implantation rate.

Fertility and sterility

Rosen MP, Shen S, Rinaudo PF, Huddleston HG, McCulloch CE, Cedars MI

Distributions of high-density lipoprotein particle components in human follicular fluid and sera and their associations with embryo morphology parameters during IVF.

Human reproduction (Oxford, England)

Browne RW, Shelly WB, Bloom MS, Ocque AJ, Sandler JR, Huddleston HG, Fujimoto VY

Coasting vs. cryopreservation of all embryos for prevention of ovarian hyperstimulation syndrome in in vitro fertilization.

Fertility and sterility

Huddleston HG, Racowsky C, Jackson KV, Fox JH, Ginsburg ES

Immune interactions at the maternal-fetal interface: a focus on antigen presentation.

American journal of reproductive immunology (New York, N.Y. : 1989)

Huddleston H, Schust DJ